This brief presents key findings from a novel social-ecological model (called Promoting, Organizing, Working, Engaging and Research out (P.O.W.E.R)) implemented in a randomized trial setting to test what works to increase the share of women in paid work and hence promote their economic empowerment. Findings reveal that a systematic and sequential implementation of individual/household plus community-level interventions can increase women’s participation in paid work activities by 35 minutes more than in the control group.